Ole Saetrum Opgaard, MD, PhD, FACE
Board Certified Specialist in Internal Medicine, Endocrinology, Diabetes and Metabolism
Assistant Professor, Department of Endocrinology, University of California, Irvine

Office Locations

9191 Westminster Ave, Suite 209
Garden Grove, CA 92844

Interactive Map Garden Grove

5475 E. La Palma Ave, Suite 208
Anaheim Hills, CA 92807

Interactive Map Anaheim Hills

24953 Paseo de Valencia, Suite 24B
Laguna Hills, CA 92653 

Interactive Map Laguna Hills

All locations:
Tel: (714) 786-5794  
Fax: (714) 786-5799


Office languages:

German, Norwegian, Spanish, Swedish, Vietnamese

Accepted Insurance:

Medicare and all major PPO-insurances accepted, including Aetna, Anthem Blue Cross, Blue Shield, Cigna, Great West Healthcare, Healthnet, Humana, Pacificare, TriCare, United Healthcare, Memorial Healthcare, Healthcare Partners, Arta, Prospect, St. Joseph Heritage Healthcare, Talbert


               Dr. Ole Saetrum Opgaard went to medical school at Westfalische Wilhelms-University in Munster, West-Germany.  He continued his specialty training in his native Norway and Sweden, and is board certified in Internal Medicine and in Endocrinology in both countries.  While working as an endocrinologist at one of the top rated academic institutions in Sweden, the University Hospital of Lund and Malmo, he also participated in endocrinology research, eventually leading to more than 20 publications in peer-reviewed international scientific journals.  This research has led to a better understanding of the role of hormones in cardiovascular regulation, and he has presented these results at the yearly scientific sessions of the American Heart Association.  Some of this research he has summarized in a book edited by one of the world’s leading authorities on endocrinology and tissue regeneration research, Professor Dame Julia M. Polak [Saetrum Opgaard O, Gulbenkian S, Edvinsson L.  Neurovascular Interactions In: (Polak, JM ed.)  Modern Visualization of The Endothelium Harwood Academic Publishers, UK 1998:59-91]. 

               After heading research projects between the University of Lund in Sweden and the Erasmus University of Rotterdam, The Netherlands, Dr. Saetrum Opgaard came to the United States with an invitation to do hormonal research at the University of California, Irvine, sponsored by the National Institutes of Health (NIH).  In order to become a licensed physician in the US, he completed the United States Medical Licensing Exams (USMLE), followed by the necessary Internship- and Residency training. Immediately afterwards, he completed a two year Fellowship in Endocrinology, Diabetes and Metabolism at the University of California, Irvine.  



               Dr. Saetrum Opgaard's  main areas of expertise are hormonal disturbances and diabetes, and his more recent research has been on metabolism and the effects of estrogen and growth hormone. He has extensive experience in the treatment of thyroid, pituitary and adrenal diseases.   
    Knowledge, dedication, respect and integrity

Professional Memberships
    American College of Physicians
    American Medical Association
    American Association of Clinical Endocrinologists 
    The Endocrine Society


Hospital Affiliations
Memorial Medical Center
     - Saddleback Memorial Medical Center, Laguna Hills 
     - Orange Coast Memorial Medical Center, Fountain Valley
    UC Irvine Medical Center
    Fountain Valley Regional Hospital
    Fountain Valley
    Placentia-Linda Hospital
    St. Joseph Hospital
Selected publications

Nutrient intake and body composition variables in Prader-Willi syndrome - effect of growth hormone supplementation and genetic subtype.
  Galassetti P, Saetrum Opgaard O, Cassidy SB, Pontello A.  J Pediatr Endocrinol Metab. 2007 Apr;20(4):491-500.

IGF-I is a matter of heart.  Saetrum Opgaard O, Wang PH.  Growth Horm IGF Res. 2005 Apr;15(2):89-94.

Investigation of CGRP receptors and peptide pharmacology in human coronary arteries. Characterization with a nonpeptide antagonist.  Hasbak P, Saetrum Opgaard O, Eskesen K, Schifter S, Arendrup H, Longmore J, Edvinsson L.  J Pharmacol Exp Ther. 2003 Jan;304(1):326-33.

Regional differences in the effect of oestrogen on vascular tone in isolated rabbit arteries.  Saetrum Opgaard O, Duckles SP, Krause DN.  Pharmacol Toxicol. 2002 Aug;91(2):77-82.

Vasoactive intestinal peptide has a direct positive inotropic effect on isolated human myocardial trabeculae.  Saetrum Opgaard O, Knutsson M, de Vries R, Tom B, Saxena PR, Edvinsson L.  Clin Sci (Lond). 2001 Dec;101(6):637-43.

Human urotensin II mediates vasoconstriction via an increase in inositol phosphates.
  Saetrum Opgaard O, Nothacker H, Ehlert FJ, Krause DN.  Eur J Pharmacol. 2000 Oct 13;406(2):265-71.

For a more extensive listing, go to www.pubmed.gov - Search for: Saetrum Opgaard



Vi Nguyen, MSN, NP-C

Education and Certifications

  • Master of Science in Nursing, California State University - Long Beach
  • Nationally Certified Family Nurse Practitioner
  • California Certified Registered Nurse
  • Bachelor of Biological Sciences, University of California - Irvine


Vi Nguyen attended the University of California at Irvine, studying biology and graduated with a Bachelor of Science in biology.  She continued her education at California State University, Long Beach, where she obtained both Bachelor and Master of Science degrees in Nursing.  During her graduate studies, she was also trained as a Family Nurse Practitioner. 
Her resident studies broadened her knowledge, gaining experience at the Long Beach Veteran’s Affairs primary outpatient clinic, Nhan Hoa Comprehensive Health Care Clinic in Garden Grove, Kaiser Permanente Downey OB/GYN Clinic, Long Beach Miller Children’s outpatient clinic, and at a private pediatric clinic in Irvine. 
Vi Nguyen enhanced her knowledge in endocrinology by interning with Dr. Ole Saetrum Opgaard. She also devoted her Master’s Research Project to the analysis of the effects of culturally competent health care providers on diabetic patients.


What is endocrinology?

Endocrinology is the study of hormones, which can be seen as messengers from one type of cell to another.  The endocrine system controls the flow of information between different cells and tissues, thereby regulating growth, puberty, menopause, appetite, body weight, sugar metabolism and bone density.
An endocrinologist is a doctor who specializes in treating disorders of the endocrine system.  The most common endocrine disorder is diabetes, followed by thyroid disease.  Other areas of endocrinology include tumors and abnormal hormonal regulation of the adrenal and pituitary glands, which can cause a multitude of symptoms and diseases.  An endocrinologist also treats disorders that can cause high blood pressure, high cholesterol and osteoporosis.

Useful links for medical information

·         American Association of Clinical Endocrinologists

·         American Diabetes Association

·         The Endocrine Society

·         The Hormone Foundation

·         UpToDate 

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